Warnings/Precautions

Avoid drinking alcohol. It can cause dangerous side effects when taken together with Endep.
Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, medicine for seizures, or other antidepressants). They can add to sleepiness caused by Endep.
Grapefruit and grapefruit juice may interact with Endep. Discuss the use of grapefruit products with your doctor before increasing or decreasing the amount of grapefruit products in your diet.
Endep can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds).
Endep can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

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